Sepsis: Early detection and implementation of a sepsis resuscitation packageIntroductionSepsis is defined as the body's inflammatory response to an infection and can quickly lead to multiple organ failure and death. Early, targeted therapy using the Sepsis Resuscitation Program introduced in the “Surviving Sepsis Campaign” is the treatment used worldwide for the treatment of sepsis (Winterbottom 2012, pp 247). There are approximately one million cases of sepsis each year in the United States, and the number of deaths exceeds that of prostate cancer, breast cancer, and HIV/AIDS combined. Additionally, more than a quarter of patients who develop sepsis will develop it in a medical-surgical unit and severe sepsis is the most common cause of death among patients in non-coronary critical units (Bernstein 2013, pp 24- 25). of all nurses, not just intensive care nurses, of the early signs and symptoms of sepsis and rapid implementation of the sepsis resuscitation program is crucial to reduce the mortality rate of sepsis. Literature review “Early recognition and treatment of sepsis in the medical-surgical setting”, focuses on the role of the nurse in being able to identify early signs of sepsis and promptly initiate sepsis treatment. In the article “The Critical Role of Nurses in Identifying Sepsis and Implementing Early Goal-Directed Therapy,” he explains how sepsis interventions reduced mortality from 37% to 30.8% in a two-year study conducted in 165 different healthcare settings. sites. This article also details the clinical guidelines and implementation deadlines for the sepsis pack. The early stages of sepsis and clinical manifestations are discussed in the article “Helping Patients Survive Sepsis,” with emphasis on the middle of the document. ......nurses are at the bedside 24 hours a day. can have a significant impact on patient outcomes and reduce the overall mortality rate from sepsis using the evidence-based practices outlined in the Surviving Sepsis campaign. Reference pageBernstein, M. and Lynn, S. (2013). Helping patients survive sepsis. American Nurse Today, 8(1), 24-28. Retrieved from http://www.americannursetoday.com/article.Gobel, B., & Peterson, G.J. (2010). Sepsis and septic shock. Clinical Journal of Oncology Nursing, 14(6), 793-797. doi:10.1188/10.CJON.793-797.Tazbir, J. (2012). Early recognition and treatment of sepsis in the medical-surgical environment. MEDSURG Nursing, 21(4), 205-209. Winterbottom, F. (2012). The essential role of nurses in identifying sepsis and implementing early goal-directed therapy. The Journal of Continuing Nursing Education, 43(6), 247-248. I:10:3928/00220124-20120523-33.