Acrylamide (AA) has a toxic effect on animals and humans. The present study investigated the potential protective effect of silymarin (SIL), as an antioxidant against AA toxicity in cardiac tissue. Say no to plagiarism. Get a tailor-made essay on “Why Violent Video Games Should Not Be Banned”? Get the original essay The rats were divided into four groups as follows: control, AA, SIL, and AA+SIL groups. The results obtained showed that AA reduces the values ​​of Hb content, PCV and red blood cell counts. Furthermore, AA enhanced the enzyme activities of LDH and CK, changed the lipid profile, digested DNA, induced oxidative stress, and developed histopathological changes in the hearts of treated rats. In contrast, the concomitant administration of AA and SIL attenuated the variation of the previous parameters, suggesting a potential protective effect of SIL against cardiac toxicity induced by AA.Practical applicationsIt is necessary to decrease the level of acrylamide in different foods. Regular consumption of SIL could provide protection to the heart and ameliorate AA-induced hematological alterations and DNA damage.IntroductionAcrylamide (AA) is a small vinyl compound. It has the chemical structure of (CH2=CO–NH2). It is used to produce polyacrylamides, which are used in wastewater treatment, dye synthesis, gel chromatography, textile processing, electrophoresis, pharmaceutical industry, photography, tapes and gels . AA is also found in tobacco smoke and is mainly produced in foods fried, roasted, grilled or baked at temperatures above 120°C. In the Maillard reaction, the NH2 of asparagine and the carbonyl group of glucose react together to produce acrylamide. Previous studies in the literature have shown that AA is absorbed very quickly and efficiently from the gastrointestinal system. The cellular toxicity of AA is initiated by its biotransformation by cytochrome P4502El into a more potent reactive molecule, glycidamide, which has more reactivity toward proteins, hemoglobin, and DNA than AA itself. AA is easily transported throughout the body due to its very small size and hydrophilic nature. Experimentally, the administration of AA can have toxic and carcinogenic effects on animals and humans. It was shown that AA could modify hematological parameters and lipid profile in treated rats. Heart disease is one of the leading causes of death worldwide. In the heart, AA caused structural changes indicating tissue degeneration. Additionally, it caused elevation of serum lactate dehydrogenase (LDH) (EC: 1.1.1.27) and creatine kinase (CK) (EC: 2.7.3.2.). AA can cause oxidative stress such as lipid peroxidation syndrome (LPO) and reduction of antioxidant enzyme activities. It is well known that administration of antioxidants alleviates drug-induced toxicity. Keep in mind: this is just a sample. Get a personalized article from our expert writers now. Get a Personalized Essay Silymarin (SIL) is produced from leaves, seeds and fruits of Silybum. marianum (milk thistle) which is part of the Asteraceae family. SIL contains flavolignans, such as taxifolin, silychristin, silydianin, silybin A, silybin B, isosilybin A and isosilybin B. SIL has multiple therapeutic effects, including antioxidant,..