Many studies have been conducted on the correlation between methamphetamine use and schizophrenia. The studies were carried out in the context of a clinical course of methamphetamine psychosis that produces awareness of the biological aspects of overcoming the paranoid psychotic state with hallucinations that occurs in schizophrenia (Sato, Numachi and Hamamura , 1992). In Japan, they conducted a series of studies on methamphetamine psychosis in people who had stopped using methamphetamine; the study lasted more than forty years (Sato et al., 1992). The permanently ineffective part of the brain that is linked to schizophrenic-like symptoms may be caused by the brain becoming tolerant to the methamphetamine-induced dopamine that is released during use of the drug, which may be linked to development of cerebral vulnerability to schizophrenic symptoms (Sato et al., 1992). There are models of chronic methamphetamine intoxication in schizophrenia in animals (Machiyama, 1992). The model was carried out by injecting small doses of methamphetamine into animals over a few weeks/months. These studies were conducted on various species of animals, ranging from guinea pigs to monkeys, and they all produced the same disorders seen in human methamphetamine users (Machiyama, 1992). It was concluded that methamphetamine users experience symptoms of schizophrenia from just one dose, and even worse when they abuse the drug further. The topic regarding schizophrenia, methamphetamine, and the likelihood that they are correlated will all be evaluated throughout this review. This literature review aims to evaluate the hypothesis that methamphetamine use increases the risk of becoming schizophrenic.Research by Nancy C. Andreasen and Michael F...... middle of article...... Get closer to the cause. Schizophrenia Bulletin, 29(3), 405-411. Retrieved from EBSCOhostFlaum, M. and Andreasen, NC (1991). Diagnostic criteria for schizophrenia and related disorders: options for the DSM-IV. Schizophrenia Bulletin, 17(1), 133-156. Retrieved from EBSCOhostLenzenweger, MF (2006).Schizotaxis, schizotypy, and schizophrenia: Paul E. Meehl's blueprint for experimental psychopathology and the genetics of schizophrenia. Journal of Abnormal Psychology, 115(2), 195-200.doi:10.1037/0021-843X.115.2.195Machiyama, Y. (1992). Chronic methamphetamine intoxication model of schizophrenia in animals. Schizophrenia Bulletin, 18(1), 107-113. Retrieved from EBSCOhostSato, M., Numachi, Y., and Hamamura, T. (1992). Relapse of Paranoid Psychotic State in Methamphetamine Model of Schizophrenia. Schizophrenia Bulletin, 18(1), 115-122. Taken from EBSCOhost