Interests and achievements in nursing research have increased in recent years, and this is very important mainly because it directly influences practice-based evidence. Therefore, there is a greater need to understand how and when qualitative and quantitative methodologies should be used, as well as the differences and similarities between them. Quantitative research essentially reflects anything that can be measured and serves to highlight, describe and analyze a problem, while qualitative research has an exploratory character because it encourages participants to think and speak freely about the phenomenon or topic, and is used to describe complex things that cannot be quantified. Identifying the problem is the first step in both cases. The theme in qualitative will always be a phenomenon because it is subjective, unique and exploratory, while in quantitative the theme is a problem or a hypothesis which will be evaluated and its result can be expressed through figures. Determining the purpose of the study, which is why the study is being done, is the second step of the two and should be clearly presented, usually in the introduction. In quantitative terms, the researcher must formulate a research question which is a specific question. question to which he expects an answer in the study. After that, he must develop a theoretical or conceptual framework, which can be defined as concepts and theories related to the subject and which serves as the basis for conducting the research. It should also identify the study's hypotheses, which are things or concepts believed to be true by the researcher, but which do not necessarily need to be proven. Then the researcher must formulate the hypothesis that shows the association...... middle of article...... achievements, and this cannot happen with qualitative results; however, both findings should be used in nursing practice, which is the final step in the research process. Another difference between these two methods concerns the researcher. While in quantitative research the researcher is separate from the study, in qualitative research he is part of the study and maintains a strict relationship with the participants, therefore confidentiality is considered essential and the researcher must therefore protect the identity of participants. The increase in interest and carrying out of research in nursing is of great relevance in tracing the comparative profiles of qualitative and quantitative methodologies. Understanding the differences between them is very important so that the person conducting the research can distinguish in which situations each method should be used...