INTRODUCTIONMultiple sclerosis is a chronic inflammatory autoimmune disease of the central nervous system, directed against the myelin sheath. Leading to demyelination and axonal loss. It is characterized by “plaques” of demelilination that are generally found on MRI in the periventricular region, the corpus callosum, the centrum semiovale and, to a lesser extent, the structures and the white basal ganglia. deep. (Olek, 2005) The clinical picture of the disease is rich and varied. It usually begins with motor symptoms accompanied by visual disturbances. Further progression depends on the part of the CNS affected. MS can present in several clinical forms, with the relapsing-remitting form being the most common in begging. The secondary progressive course is sequential and gives a much worse prognosis. The benign form, although not well defined, is generally a random finding on MRI and presents no clinical symptoms. In the most severe cases, MS can lead to death. The etiology of the disease is not yet known. There is discussion that there is an action of one or more exogenous factors which, after a long latency period, trigger the disease in genetically susceptible individuals. MS is characterized by a geographic and demographic distribution, with frequency increasing away from the equator and decreasing again in polar regions. Around 30/100,000 people suffer from the disease worldwide. This diploma thesis is composed of two parts – theoretical and practical. The theoretical part describes the most recent discoveries of pathogenesis, an overview of the typical clinical picture, the most common diagnostic methods, especially the investigation of OCB, and the classical and modern threats of the disease. The practical part is a survey...... in the middle of a paper...... lasting a few minutes but can be repeated several times a day. The group includes paroxysmal paresthesias, trigeminal neuralgia, painful tonic spasms, paroxysmal dysatria and ataxia, paroxysmal diplopia, paroxusmic dyskinesia, facial myokymia. Here we can also include Lhermitte's symptom.11. FatigueAnother common symptom. Generally, it is described as fatigue not linked to physical exhaustion. There is no link to muscle weakness or fatigue. There is a lack of initiative for physical or mental activity, after rest there is only partial recovery. The patients are even tired. Usually, these symptoms are experienced in the afternoon, correlating with the daily circadian rhythm.4.2 Clinical courseThe disease has an unpredictable clinical course. This means that it is difficult to give a prognosis in a single patient. Nevertheless, today there is a clinical division used.